The mellow river is surrounded by wetlands that get flooded in the rainy season, forming a vast lake. The most scenic stretch of the river is the Cano Negro portion, a scene reminiscent of the Florida everglades. This area is also home to an abundance of underwater wildlife including fresh water sharks, caimans and hundreds of amphibians and reptiles.

Safari floats, which provide fantastic wildlife and scenic views, are the most popular activity on Río Frío. But the river is also great for fishing. Snook, guapote, alligator gar, drum and tarpons that have been known to weigh as much as 220 lbs (100 kg) all populate this river's waters.